Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are a polymorphic group of clinical disorders comprising the major cause of renal failure in children.Included within CAKUT is a wide spectrum of developmental malformations ranging from Card Reader renal agenesis, renal hypoplasia and renal dysplasia (maldifferentiation of renal tissue),
We have engineered an integration-deficient lentiviral vector, LV305, to deliver the tumor antigen NY-ESO-1 to human dendritic cells in vivo through pseudotyping with a modified Sindbis virus envelop protein.Mice immunized once with LV305 developed strong, dose-dependent, multifunctional, and cytotoxic NY-ESO-1-specific cluster of differentiation 8
Liver cancer remains one of the most formidable challenges in modern medicine, characterized by its high incidence and mortality rate.Emerging evidence underscores the Ringette Ring critical roles of the immune microenvironment in tumor initiation, development, prognosis, and therapeutic responsiveness.However, the composition of the immune microen
The Effects Doctrine creates an important basis for the application of local law outside of its territory.It reflects the understanding that in this day and age, actions taken in one jurisdiction can significantly affect other jurisdictions.The use of competition law extraterritorial jurisdiction, based on the effects doctrine, has long been debate